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Target intelligence / Profile preview
CD70 receptor (CD70)
- Target
- CD70
- Molecular classification
- Cell surface glycoprotein, Tumor Necrosis Factor Superfamily
01
Overview
The CD70 receptor is a tightly regulated costimulatory molecule essential for robust yet controlled adaptive immunity. Its dysregulation contributes directly to cancer progression but also offers opportunities for targeted immunotherapy interventions across oncology and immunology fields.
- Other names
- CD27 ligandCD27LTNFSF7Cluster of Differentiation 70
02
Mechanism of action
Targeted therapies against CD70 expressing cells
03
Biological functions
Costimulatory signalingT-cell activationB-cell activationT-cell proliferationB-cell proliferationT-cell survivalB-cell survivalT-cell differentiationB-cell differentiationImmune regulationMemory formationNegative feedback/checkpoint control
04
Disease associations
CancerAutoimmune DiseaseTransplantation
05
Safety considerations
Excessive inflammatory responsesAutoimmunityGraft-versus-host disease
06
Interacting drugs
Anti-CD70 antibodies
1 more in the full profile.
07
Biomarkers
CD70 expression level in tumor cellsCD70 expression on alloreactive/inflammatory T-cells
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