Target intelligence / Profile preview

CD75s Epitope (CD75s)

Target: CD75s
Molecular classification: Glycan, Carbohydrate antigen, Glycoprotein, Ganglioside

Overview

CD75s is a cell surface epitope defined by an α2,6-sialylated glycan structure. It is overexpressed or aberrantly presented in several malignancies, including lymphomas, myeloma, prostate cancer and melanoma, making it a therapeutic target for antibody-based therapies and immunotoxins like Aviscumine. Its biological function is not completely understood but it is associated with glycosylation patterns and immune recognition.

Other names: α2,6-sialylated glycanLN-1 antigen

Mechanism of action

Antibody-dependent cellular cytotoxicity (ADCC), phagocytosis (for Fc-engineered antibodies); Cytotoxic effects via lectin binding and A chain activity (for Aviscumine)

Biological functions

Modulating immune recognitionCellular interactionsAssociated with altered glycosylation

Disease associations

CancerLymphomaPlasma cell tumorsMultiple myelomaProstate cancerMelanoma

Interacting drugs

EBU-141 Tetra

1 more in the full profile.

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