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Target intelligence / Profile preview
CD79a molecule (Igα)
- Target
- Igα
- Molecular classification
- Immunoglobulin superfamily, Receptor
01
Overview
CD79a, also known as Igα or MB-1, is a membrane glycoprotein essential for B cell development and function. It forms a heterodimer with CD79b and associates with membrane immunoglobulins to form the B cell antigen receptor (BCR) complex. Upon antigen binding, the ITAM motifs in its cytoplasmic tail mediate signal transduction. It is a potential target for cancer therapy research due to its restricted expression pattern on malignant versus non-malignant tissues. Mutations can result in agammaglobulinemia type 3.
- Other names
- MB-1CD79A
02
Mechanism of action
Recruitment of kinases upon antigen binding, leading to downstream activation of BTK, PLCγ2, NF-kB, PI3K/AKT pathways
03
Biological functions
B cell receptor signalingSignal transductionB cell developmentImmune response
04
Disease associations
Agammaglobulinemia type 3Cancer
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