Molecular Classification
Receptor, Type I transmembrane glycoprotein, Immunoglobulin superfamily
Other Names
Ig-beta, IGB, AGM6, B29
Disease Roles
AgammaglobulinemiaLymphoma

CD79b molecule Overview

CD79B is a crucial component of the B-cell antigen receptor (BCR) complex. It forms a heterodimer with CD79A, which then associates with surface immunoglobulin to form the functional BCR on B lymphocytes. This complex initiates intracellular signaling upon antigen binding, essential for B cell development, activation, and immune response. Mutations in CD79B are associated with agammaglobulinemia, and specific mutations serve as biomarkers in lymphoma.

Mechanism of Action

Not applicable

Biological Functions

Signal transduction
B cell development
B cell activation
Immune response
Antigen recognition

Disease Associations

Agammaglobulinemia
Lymphoma

Safety Considerations

No safety concerns listed

Associated Biomarkers

Biomarker
Y196 mutation (predictive marker for response to R-MPV therapy in primary central nervous system lymphoma)