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CD8+ T cell activation via cross-presentation
- Molecular classification
- Immune Process, Antigen Presentation Pathway
01
Overview
CD8+ T cell activation via cross-presentation refers to the process by which certain professional antigen-presenting cells (APCs), primarily dendritic cells (DCs), present extracellular (exogenous) antigens on major histocompatibility complex class I (MHC I) molecules to naive CD8+ T cells. This mechanism is distinct from the classical pathway, where endogenous antigens are presented on MHC I, and is essential for initiating cytotoxic immune responses against pathogens that do not directly infect APCs, as well as for anti-tumor immunity.
02
Biological functions
Immune responseT cell activationCytotoxicityAntigen presentationTolerance induction
03
Disease associations
Viral infectionTumor immunityAutoimmunity
04
Safety considerations
Autoimmunity if tolerance mechanisms fail
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