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Target intelligence / Profile preview
CD8-Positive Effector Memory T Cell (CD8+ Tem)
- Target
- CD8+ Tem
- Molecular classification
- T lymphocyte, Effector cell, Memory cell
01
Overview
CD8-positive effector memory T cells (CD8+ Tem) are a subset of memory T lymphocytes that provide rapid immune protection against previously encountered antigens. They are characterized by their ability to quickly exert effector functions, such as cytotoxicity and cytokine production, upon re-exposure to antigen. CD8+ Tem cells are identified by their CD45RA− CCR7− phenotype and their presence in blood and peripheral tissues. They play a critical role in defense against intracellular pathogens and tumor surveillance.
- Other names
- CD8+ Effector Memory T CellEffector Memory CD8 T CellTem CD8+CD8 Tem
02
Biological functions
CytotoxicityCytokine productionImmune responseAntigen recognitionAdaptive immunityTumor surveillance
03
Disease associations
InfectionCancerAutoimmunity (potential)
04
Safety considerations
Potential for excessive inflammationPossible role in autoimmunityCytokine storm potential
05
Biomarkers
CD45RA−CCR7−IFNγ productionTNFα production
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