CD8B family member 2 (CD8B2)

CD8B family member 2 (CD8B2), also known as "putative T-cell surface glycoprotein CD8 beta-2 chain," is classified as a pseudogene in humans[5][6]. A pseudogene is a DNA sequence similar to a functional gene but generally non-functional due to mutations or lack of expression. While the canonical CD8B gene encodes the beta subunit of the CD8 molecule, which is a vital co-receptor on cytotoxic T lymphocytes involved in immune responses[1][2], CD8B2 is not established as a functional gene or as a receptor/therapeutic target. The function and relevance of the CD8B2 gene product are not clearly supported, with multiple gene and protein databases annotating it as a pseudogene or as a putative, non-evidenced protein product[5][6]. There are no established biological or disease roles, drug interactions, or clinical utility for CD8B2, and no evidence supports its use as a biomarker or therapeutic target.

Other names

CD8B family member 2CD8B2Putative T-cell surface glycoprotein CD8 beta-2 chainCD8BPCD8b pseudogeneCD8 antigen, beta polypeptide pseudogeneCD8b molecule pseudogeneCD8b2 molecule