CD93 antigen (CD93)

CD93 antigen (CD93) is a heavily glycosylated type I transmembrane glycoprotein encoded by the CD93 gene, consisting of 652 amino acids with a predicted mass of 68 kDa but migrating at 110-126 kDa due to glycosylation. It features a C-type lectin-like domain, epidermal growth factor-like repeats, mucin-like domain, transmembrane domain, and short cytoplasmic tail that interacts with moesin for cytoskeletal linkage. Expressed on hematopoietic stem cells, endothelial cells, monocytes, neutrophils, platelets, microglia, and B cell precursors, CD93 promotes cell adhesion, migration, phagocytosis of apoptotic cells and immune complexes, endothelial dynamics via MMRN2 and fibronectin interactions, and angiogenesis. Though initially thought to be a C1q receptor, direct interaction is unconfirmed; it regulates VEGFR2 and supports tumor vascularization in cancers like glioma and AML

Other names

C1qRpC1QR1C1qR1C1q receptorcomplement C1q receptorGR11AA4.1MXRA4

antiangiogenic therapy by inhibiting endothelial cell proliferation migration and sprouting, targeting CD93 for AML cell proliferation inhibition