Target intelligence / Profile preview

CD93 molecule (CD93)

Target: CD93
Molecular classification: C-type lectin receptor, Transmembrane glycoprotein

Overview

CD93 is a C-type lectin transmembrane glycoprotein receptor involved in cell adhesion, host defense, angiogenesis, phagocytosis, and immune regulation. It is expressed on endothelial cells, myeloid cells, and hematopoietic stem cells, and exists in both membrane-bound and soluble forms. CD93 plays a role in various diseases, including cancer, glioma, acute myeloid leukemia, and psoriasis, making it a potential therapeutic target.

Other names: Complement component 1q subcomponent receptorC1qR1C1qRp

Mechanism of action

Unknown, targets in development

Biological functions

Cell-cell adhesionHost defenseAngiogenesisPhagocytosisCell migrationImmune regulationMonocyte differentiation

Disease associations

CancerGliomaAcute Myeloid Leukemia (AML)Psoriasis

Safety considerations

Potential for off-target effects due to broad expressionModulation of angiogenesis could have unintended consequencesDisruption of phagocytosis could impair immune function

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