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Target intelligence / Profile preview
CD94
- Target
- CD94
- Molecular classification
- Type II transmembrane glycoprotein, C-type lectin-like receptor
01
Overview
CD94 is a C-type lectin transmembrane glycoprotein predominantly expressed on the surface of natural killer (NK) cells and a subset of CD8+ T lymphocytes. It forms heterodimers with members of the NKG2 family (NKG2A, NKG2C, and NKG2E), resulting in either inhibitory or activating receptor complexes. The primary ligand is HLA-E, a nonclassical MHC class I molecule. CD94/NKG2 receptor complexes regulate NK cell cytotoxicity by delivering either activating or inhibitory signals depending on their composition, playing roles in maintaining self-tolerance and contributing to immune responses against virally infected or tumorigenic cells.
- Other names
- KLRD1
02
Mechanism of action
Modulation of NK cell activity by binding to HLA-E and delivering activating or inhibitory signals
03
Biological functions
Immune regulationRegulation of NK cell cytotoxicityRegulation of T-cell activationSelf-toleranceImmune surveillance
04
Disease associations
Infection controlCancer immunityAutoimmunity regulationTransplantation outcomes
05
Safety considerations
Potential for off-target effects due to broad expression on NK cells and CD8+ T cellsComplex signaling pathways involving activating and inhibitory signals require careful modulationPotential for autoimmunity if self-tolerance mechanisms are disrupted
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