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Target intelligence / Profile preview
CD95 Antigen (CD95)
- Target
- CD95
- Molecular classification
- Receptor, Type I transmembrane glycoprotein, Tumor Necrosis Factor Receptor superfamily
01
Overview
CD95 (Fas/APO-1/TNFRSF6) is a type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It plays a crucial role in apoptosis, immune regulation, and cancer biology. Upon binding to its ligand, CD95L, it initiates programmed cell death through the recruitment of caspase-8. While primarily known for its pro-apoptotic function, CD95 can also influence cell proliferation and immune responses. Its expression is widespread, particularly in immune cells and various tissues. Dysregulation of CD95 signaling is implicated in autoimmunity, lymphoproliferative disorders, and cancer. Loss or mutation of CD95 correlates with more aggressive tumor phenotypes.
- Other names
- FasAPO-1TNFRSF6
02
Mechanism of action
Agonistic antibodies induce apoptosis
03
Biological functions
ApoptosisImmune regulationCell deathCell proliferation
04
Disease associations
CancerAutoimmunityLymphoproliferative disordersImmune dysregulation
05
Safety considerations
Potential for off-target effects due to widespread expressionResistance mechanisms in cancer cells limiting therapeutic efficacyInduction of excessive apoptosis leading to tissue damage
06
Biomarkers
Expression levels in hematologic malignancies (e.g., Non-Hodgkin's lymphoma)
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