Target intelligence / Profile preview

CD95 Ligand (CD95L)

Target: CD95L
Molecular classification: Type II transmembrane protein, Tumor necrosis factor (TNF) superfamily member

Overview

CD95L is a type II transmembrane protein belonging to the TNF superfamily. It exists in both membrane-bound and soluble forms. The membrane-bound form, a homotrimer, induces apoptosis in target cells expressing CD95. The soluble form, generated by proteolytic cleavage, is less potent in inducing apoptosis but can modulate immune responses. CD95L plays roles in immune homeostasis, immune privilege, and inflammation. In cancer, it can promote tumor progression via enhanced migration and invasion.

Other names: Fas ligandFasLApo-1LCD178TNFSF6

Mechanism of action

N/A

Biological functions

Apoptosis inductionImmune regulationChemokine-like activityCell motilityCell differentiationCell proliferationCell survivalInflammation

Disease associations

AutoimmunityLymphoproliferative disordersCancerTransplantation

Safety considerations

Potential promotion of tumor progression via enhanced migration/invasionComplex effects on tumor microenvironment dynamics including potential promotion of metastasis under certain conditionsDysregulation of lymphocyte death/survival balance leading to autoimmune diseases

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