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Target intelligence / Profile preview
CD95 Receptor (CD95)
- Target
- CD95
- Molecular classification
- Tumor necrosis factor receptor superfamily, Type I transmembrane glycoprotein, Death receptor
01
Overview
The CD95 receptor, also known as Fas, is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. It plays a critical role in programmed cell death (apoptosis) and other cellular functions. Upon ligand binding, CD95 activates apoptotic signaling pathways, leading to caspase activation and cell death. It is involved in immune system regulation, tissue homeostasis, and responses to cellular stress. Dysregulation of CD95 signaling is implicated in autoimmune disorders and cancer.
- Other names
- FasFasRAPO-1Apoptosis antigen 1APTTNFRSF6Tumor necrosis factor receptor superfamily member 6
02
Biological functions
ApoptosisImmune system regulationTissue homeostasisActivation-induced cell death (AICD)Signal transductionCell deathCell proliferation
03
Disease associations
Autoimmune disordersCancerLymphoproliferative conditionsSystemic lupus erythematosusAutoimmune lymphoproliferative syndrome (ALPS)
04
Safety considerations
Potential for immune-related adverse eventsTumor promotion via non-apoptotic signalingOff-target effects due to widespread expression
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