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Target intelligence / Profile preview
CD98 heavy chain (CD98hc)
- Target
- CD98hc
- Molecular classification
- Type II transmembrane glycoprotein, Amino acid transporter, Solute carrier
01
Overview
CD98 is a multifunctional cell surface glycoprotein, best known as the heavy chain component of heterodimeric amino acid transporters, particularly the large neutral amino acid transporter (LAT1). It plays a crucial role in amino acid transport, cell adhesion, integrin signaling, and immune regulation. It is overexpressed in various cancers and is a target for antibody-based therapies.
- Other names
- 4F2hc4T2HCMDU1NACAESLC3A2
02
Mechanism of action
Targeted therapies using anti-CD98 antibodies are under investigation. pH-dependent antibody variants enhance tumor-specific activity.
03
Biological functions
Amino acid transportCell adhesionCell migrationIntegrin signalingImmune regulation
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Widespread expression complicates targeted therapies.
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