Molecular Classification
Type II transmembrane glycoprotein, Amino acid transporter, Solute carrier
Other Names
4F2hc, 4T2HC, MDU1, NACAE, SLC3A2
Disease Roles
CancerDevelopmental disorders

CD98 heavy chain Overview

CD98 is a multifunctional cell surface glycoprotein, best known as the heavy chain component of heterodimeric amino acid transporters, particularly the large neutral amino acid transporter (LAT1). It plays a crucial role in amino acid transport, cell adhesion, integrin signaling, and immune regulation. It is overexpressed in various cancers and is a target for antibody-based therapies.

Mechanism of Action

Targeted therapies using anti-CD98 antibodies are under investigation. pH-dependent antibody variants enhance tumor-specific activity.

Biological Functions

Amino acid transport
Cell adhesion
Cell migration
Integrin signaling
Immune regulation

Disease Associations

Cancer
Developmental disorders

Safety Considerations

  • Widespread expression complicates targeted therapies.