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CDC like kinase 2 (CLK2)

Target: CLK2
Molecular classification: Enzyme, Dual specificity protein kinase

Overview

CDC-like kinase 2 (CLK2) is a dual specificity protein kinase that phosphorylates both serine/threonine and tyrosine residues. It regulates RNA splicing by phosphorylating SR proteins and is involved in cell cycle progression, apoptosis, telomere length regulation, DNA damage repair, and chemoresistance. Elevated CLK2 expression is associated with several cancers and chemoresistance, making it a potential therapeutic target.

Mechanism of action

Inhibition of CLK2 kinase activity

Biological functions

Phosphorylation of SR proteinsRNA splicing regulationCell cycle regulationApoptosis regulationTelomere length regulationDNA damage repair

Disease associations

CancerChemoresistance

Biomarkers

CLK2 expression levels in cancer cells

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