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CDC-like kinase 4 (CLK4)

Target: CLK4
Molecular classification: Enzyme, Dual specificity kinase, Protein kinase

Overview

CLK4 is a member of the CDC2-like protein kinase (CLK) family, which are dual specificity kinases capable of phosphorylating both serine/threonine and tyrosine residues. This protein plays a role in the regulation of RNA splicing by phosphorylating serine- and arginine-rich (SR) proteins. Recent studies have linked CLK4 to the regulation of cardiac hypertrophy through phosphorylation of nexilin (NEXN), suggesting it as a potential therapeutic target for heart failure.

Mechanism of action

Inhibition of CLK4 kinase activity to modulate SR protein phosphorylation and RNA splicing; modulation of NEXN phosphorylation.

Biological functions

Regulation of RNA splicingPhosphorylation of SR proteinsRegulation of cardiac hypertrophy

Disease associations

Fanconi Anemia, Complementation Group ANoonan Syndrome 1Cardiac hypertrophyHeart failure

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