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Target intelligence / Profile preview
CDC2-like kinase 3 (CLK3)
- Target
- CLK3
- Molecular classification
- Enzyme, Kinase, Serine/threonine protein kinase, Dual-specificity protein kinase, Cdc2-like kinase
01
Overview
CDC2-like kinase 3 (CLK3) is a serine/threonine protein kinase involved in the regulation of pre-mRNA splicing through phosphorylation of serine/arginine-rich (SR) proteins. CLK3 influences gene expression at the post-transcriptional level by modulating how pre-mRNAs are processed into mature mRNAs. It is broadly expressed, with notable localization to cytoplasmic stress granules in testes tissue. Its active site pocket structure, particularly the unique Lys248 residue, influences inhibitor binding affinity/selectivity.
02
Mechanism of action
Inhibition of CLK3 kinase activity
03
Biological functions
Regulation of pre-mRNA splicingPhosphorylation of SR proteinsRegulation of gene expressionSpliceosome assembly/functionality
04
Disease associations
CancerOther
05
Safety considerations
Potential for off-target effects due to structural similarities with other CLK isoformsAltered splicing can have pleiotropic effects
06
Interacting drugs
CX-4945
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