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Target intelligence / Profile preview
CDC2-like kinase 4 (None)
- Target
- None
- Molecular classification
- Enzyme, Protein Kinase, Dual-specificity kinase, Cdc2-like kinase (CLK) family
01
Overview
CDC2-like kinase 4 is an important regulator in mRNA processing through its control over alternative splicing via phosphorylation events on SR proteins. Its dysregulation contributes to several pathologies including cancers and neurodegenerative diseases. As such it represents an attractive target for drug discovery efforts focused on modulating RNA processing pathways in disease contexts.
02
Mechanism of action
Inhibition of CLK4 leads to altered phosphorylation patterns on SR proteins, affecting splice variant production.
03
Biological functions
Regulation of alternative splicingPhosphorylation of SR proteinsChromatin integrity
04
Disease associations
CancerNeurodegenerative diseaseHIV-1 infectionInfluenza virus infectionDuchenne muscular dystrophy
05
Interacting drugs
TG003
1 more in the full profile.
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