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Target intelligence / Profile preview
Cdc2-related kinase 12 (CRK12)
- Target
- CRK12
- Molecular classification
- Enzyme, Protein Kinase, Cyclin-dependent kinase (CDK)
01
Overview
Cdc2-related kinase 12 (CRK12) is a cyclin-dependent kinase involved in cell cycle regulation and transcriptional control. In humans, the ortholog is CDK12, which phosphorylates the C-terminal domain of RNA polymerase II, regulating transcription of genes involved in DNA repair and genome stability. In protozoan parasites like Leishmania donovani and Trypanosoma brucei, CRK12 is essential for proliferation and survival, making it a potential drug target. Inhibition of CRK12 in parasites leads to cell death.
- Other names
- CRK7KIAA0904CRKRCell Division Cycle 2-Related Protein Kinase 7Cyclin Dependent Kinase RS (CrkRS)CDK12
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
Cell cycleTranscription regulationDNA repairRNA splicingMAP kinase activity regulation
04
Disease associations
CancerInfectionCongenital heart defectsIntellectual developmental disorder
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