Target intelligence / Profile preview

Cdc25C-associated protein kinase 1 (C-TAK1)

Target: C-TAK1
Molecular classification: Serine/threonine-protein kinase

Overview

C-TAK1 is a serine/threonine-protein kinase that regulates cell cycle progression by phosphorylating Cdc25C on serine 216. This phosphorylation event mediates binding of the 14-3-3 protein, sequestering Cdc25C in the cytoplasm during interphase and preventing premature entry into mitosis. Unlike Chk1, C-TAK1 appears to function independently under normal conditions. Dysregulation could potentially contribute to aberrant cell cycle control, a hallmark of cancer.

Other names: Not to be confused with TAK1 (MAP3K7) or TAO kinases such as TAOK1

Mechanism of action

Phosphorylation of Cdc25C on serine 216, leading to 14-3-3 binding and cytoplasmic sequestration

Biological functions

Cell cycle regulationSignal transduction

Disease associations

Cancer (potential, via cell cycle dysregulation)

Safety considerations

Dysregulation could contribute to aberrant cell cycle control

Beyond the preview

Go deeper on Cdc25C-associated protein kinase 1 (C-TAK1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cdc25C-associated protein kinase 1 (C-TAK1).

Explore the full profile