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Target intelligence / Profile preview
CDC28 protein kinase regulatory subunit 1B pseudogene 7 (CKS1BP7)
- Target
- CKS1BP7
- Molecular classification
- Pseudogene
01
Overview
CDC28 protein kinase regulatory subunit 1B pseudogene 7 (CKS1BP7) is a non-coding pseudogene in humans, related to the functional CDC28 protein kinase regulatory subunit 1B (CKS1B) gene. While pseudogenes were once considered "junk DNA," increasing evidence indicates that many—such as CKS1BP7—can play regulatory roles in gene expression. CKS1BP7 appears upregulated in some breast cancer tissues, where it may enhance cell proliferation by interacting with genes like IGF1R. Nevertheless, it does not encode a functional protein, and there are no current drugs that directly target this pseudogene. Its utility has been explored in cancer diagnostics as a molecular biomarker, particularly through DNA or RNA profiling in tumors[2][5][8][9].
- Other names
- CKS1ACKS1
02
Biological functions
Regulation of gene expression (as a pseudogene, via competing endogenous RNA/ceRNA mechanisms in some contexts)
03
Disease associations
Cancer (notably breast cancer, via gene co-amplification and functional associations)
04
Biomarkers
Proposed for cancer diagnosis or molecular profiling (via genomic detection or expression as in breast cancer)
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