Cdc42 effector protein 2 (CDC42EP2)

**Cdc42 effector protein 2 (CDC42EP2)** is a member of the Borg family of CDC42 effector proteins, which contain a CRIB (Cdc42/Rac interactive-binding) domain and are involved in the regulation of the actin cytoskeleton[1][2][3][4]. CDC42EP2 interacts with the small Rho GTPase CDC42 and RHOQ and acts as a downstream effector that induces actin filament assembly and promotes formation of pseudopodia, contributing to cell shape control and differentiation[1][2][3][4]. This protein is primarily classified as a cytoskeletal regulator rather than a canonical therapeutic target such as a receptor or enzyme[1][2][3][4]. There are currently no drugs known to directly target CDC42EP2, and no specific mechanisms of action or safety concerns have been documented for therapeutic intervention. It is also known by the aliases BORG1 and CEP2[3][4].

Other names

BORG1CEP2binder of Rho GTPases 1CRIB-containing BORG1 protein