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Cdc42 effector protein 3 (CDC42EP3)
- Target
- CDC42EP3
- Molecular classification
- Cdc42 effector protein family, CRIB domain-containing protein, actin cytoskeleton regulator
01
Overview
Cdc42 effector protein 3 is a member of the Borg (binder of Rho GTPases) family and contains a CRIB domain, enabling it to bind to and regulate CDC42, a small Rho GTPase important in actin cytoskeleton dynamics. The protein is implicated in actin filament assembly, cell shape changes, and formation of pseudopodia, acting as a downstream modulator of CDC42 signaling. It interacts with CDC42 and RHOQ, and has been linked to cancer progression, notably gastric cancer, through its role in cytoskeletal reorganization. Multiple transcript variants exist due to alternative splicing, and a pseudogene is present on chromosome 19
- Other names
- CDC42EP3BORG2CEP3UB1Binder of Rho GTPases 2MSE55-related Cdc42-binding proteinCRIB-containing BORG2 protein
02
Biological functions
Actin cytoskeleton organizationCell shape changesInduction of pseudopodia formationSignal transduction downstream of CDC42 (small Rho GTPase)
03
Disease associations
Cancer (notably involved in gastric cancer and superficial urinary bladder cancer, associated with cell shape changes and potentially tumor progression)Other (developmental roles indicated in mouse genetics, but human disease relevance is primarily noted for certain cancers)
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