CDC42 small effector protein 2 (CDC42SE2)

CDC42 small effector protein 2 (CDC42SE2) is a member of the small CDC42-binding effector protein family characterized by a CRIB (Cdc42/Rac interactive-binding) domain. It acts downstream of the small GTPase CDC42—regulating actin cytoskeletal reorganization, actin filament assembly, cell shape, and survival responses to stress such as proteasome inhibition. In immune cells, it helps coordinate F-actin accumulation at the immunological synapse and may be involved in early stages of phagocytosis. Although not itself considered a classical therapeutic target such as a receptor or enzyme, CDC42SE2 can modulate cellular responses to anti-cancer agents and has been implicated in cancer cell resistance. Its function likely involves functioning as a signaling adaptor protein at the plasma membrane, fine-tuning CDC42-driven signaling cascades important for various cellular and disease contexts.

Other names

SPEC2FLJ21967Small effector of CDC42 protein 2non-kinase Cdc42 effector protein SPEC2

No specific drugs directly target CDC42SE2. Indirect targeting (e.g., knockdown of CDC42SE2) increases sensitivity to proteasome inhibition (bortezomib) in cancer cells, associating its activity with cell survival pathways.