CDGSH iron-sulfur domain-containing protein 2 (CISD2)

CDGSH iron-sulfur domain-containing protein 2 (CISD2) is a membrane-associated member of the NEET protein family characterized by a conserved CDGSH motif that binds a [2Fe-2S] iron-sulfur cluster. CISD2 is located predominantly at the endoplasmic reticulum and mitochondria-associated membranes, where it regulates autophagy, apoptosis, and iron/ROS balance. Its biological roles make it relevant to multiple disease processes, including metabolic disorders, cancer, neurodegenerative diseases, and cardiovascular disease. CISD2 functions by maintaining mitochondrial integrity, antagonizing BECN1-mediated autophagy, and controlling mitochondrial signaling related to cell death and survival. Dysfunction or altered expression of CISD2 has been implicated in aging, neurodegeneration, and susceptibility to metabolic syndromes.

Other names

CISD2ZCD2Miner1CDGSH iron-sulfur domain 2

Drugs (or research compounds) targeting CISD2 are postulated to modulate mitochondrial iron-sulfur cluster transfer, regulate ROS, impact apoptosis, or modulate autophagy