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Target intelligence / Profile preview
CDH18 Antisense RNA 1 (CDH18-AS1)
- Target
- CDH18-AS1
- Molecular classification
- Other, long non-coding RNA, Antisense RNA
01
Overview
CDH18 Antisense RNA 1 (CDH18-AS1) is a long non-coding RNA gene located antisense to the *CDH18* gene. As an antisense transcript, it may regulate *CDH18* expression by mechanisms such as transcriptional interference, RNA-RNA interaction, or chromatin modification, as seen in other lncRNAs of this class[2][4]. There is no evidence that CDH18-AS1 functions as a receptor, enzyme, or direct therapeutic target. No clear disease associations, biomarker roles, or drug interactions have been reported for CDH18-AS1 to date.
- Other names
- CDH18 Antisense RNA 1CDH18-AS1
02
Mechanism of action
Not applicable; no drugs are reported to target CDH18-AS1 directly
03
Biological functions
Regulation of gene expression (via antisense mechanisms)Potential modulation of chromatin structure, transcription, or translation through interactions with mRNA or protein complexesPossible involvement in imprinting or epigenetic regulation (generic to antisense RNAs)
04
Disease associations
No direct disease association reported for CDH18-AS1 to dateBy analogy to other antisense RNAs, possible involvement in cancer, neuropsychiatric traits, or metabolic regulation through modulation of CDH18 expression, but this remains speculative
05
Safety considerations
None known or reported; antisense RNAs in general can be challenging to target or modulate without off-target effects, but this is generic to the RNA class
06
Biomarkers
None specifically reported for CDH18-AS1. The CDH18 gene/protein is being studied as a putative cancer biomarker, but not its antisense transcript
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