CDH23 antisense RNA 1 (CDH23-AS1)

CDH23 antisense RNA 1 (CDH23-AS1) is a long non-coding RNA gene transcribed from the opposite DNA strand of the coding cadherin-related 23 (CDH23) gene, the latter being involved in cell-cell adhesion and having known pathogenic mutations linked to hearing loss and Usher syndrome[4][7]. CDH23-AS1 belongs to the family of antisense RNAs, which often function in gene regulation through interactions with the corresponding sense (protein-coding) gene[2][4][9]. For CDH23-AS1, no direct functional or mechanistic studies have been published in the literature or major databases to date; its possible roles are inferred from general properties of antisense lncRNAs. It is affiliated with disease association entries such as pituitary adenoma and Usher syndrome, type Id, though these are not mechanistically confirmed. CDH23-AS1 is not considered a therapeutic target at present, and no drugs, mechanisms of drug action, known biomarkers, or safety concerns are recorded[2][4][10]. The gene is annotated with several aliases across databases: bA327E2.3, C10orf106, NCRNA00223, and CDH23 antisense RNA 1 (non-protein coding)[2][3][8][10].

Other names

bA327E2.3C10orf106NCRNA00223CDH23 antisense RNA 1 (non-protein coding)