Target intelligence / Profile preview

CDH3 antisense RNA 1 (CDH3-AS1)

Target: CDH3-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA, Noncoding RNA gene

Overview

CDH3 antisense RNA 1 (CDH3-AS1) is a long non-coding antisense RNA gene overlapping the CDH3 locus, which encodes P-cadherin, a cell adhesion protein important in tissue integrity. CDH3-AS1 is highly downregulated in melanoma, and its overexpression promotes tumor-suppressive effects by enhancing P-cadherin translation, increasing cell aggregation, and reducing tumor growth in models. Mechanistically, CDH3-AS1 interacts with CDH3 mRNA, modulating its translation via ribosomal recruitment, and represents a broader class of antisense regulatory RNAs that influence protein-coding gene expression, particularly in cancer.

Other names: CDH3-AS1

Biological functions

Regulation of translation (specifically enhances P-cadherin translation)Regulation of cell adhesion through influence on CDH3 mRNATumor Suppression in melanoma (increases cell aggregation, reduces tumor growth in models)RNA-RNA interaction (interacts with CDH3 mRNA to modulate ribosome occupancy)

Disease associations

Cancer (notably melanoma, potential involvement in other cancers)Possibly congenital disorders associated with P-cadherin, via regulation

Biomarkers

Expression level of CDH3-AS1 may serve as a biomarker of tumor suppression or cancer progression in melanoma

Beyond the preview

Go deeper on CDH3 antisense RNA 1 (CDH3-AS1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on CDH3 antisense RNA 1 (CDH3-AS1).

Explore the full profile