CDH4 antisense RNA 2 (CDH4-AS2)

CDH4 antisense RNA 2 (CDH4-AS2) is presumed to be a long non-coding RNA located at or near the CDH4 (Cadherin-4) gene locus. While lncRNAs in this region, such as linc-cdh4-2, have been implicated in suppression of migration and invasion in cancer cell models (notably HCC), the specific functional identity and role of CDH4-AS2 remain poorly characterized in the literature and biological databases. There is some evidence that overexpression of antisense lncRNAs at CDH4 may upregulate R-cadherin (CDH4), decrease RAC1 expression, and inhibit cell migration—suggesting a tumor suppressor function[4]. However, direct therapeutic targeting of CDH4-AS2 has not been established. Limitations: - There is no confirmatory evidence that "CDH4-AS2" is a formally recognized molecule in major databases; it may be mis-labeled, predicted, or not yet widely annotated in canonical resources. - Most functional understanding in the literature comes from related or overlapping entities (e.g., linc-cdh4-2), not the exact term CDH4-AS2[4]. Summary: CDH4-AS2 is a likely long non-coding antisense RNA associated with the CDH4 gene, potentially with tumor suppressor function in some cancers via modulation of cell migration and invasion, but it is neither a conventional drug target nor well-defined in current canonical resources[4].

Other names

linc-cdh4-2CDH4 antisense lncRNA