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Target intelligence / Profile preview
CDKN2A interacting protein N-terminal like (CDKN2AIPNL)
- Target
- CDKN2AIPNL
- Molecular classification
- Other (CARF family protein)[1][2]
01
Overview
CDKN2A interacting protein N-terminal like (CDKN2AIPNL) is a protein-coding gene member of the CARF family, with two human isoforms generated by alternative splicing[1][3]. It is found predominantly in the nucleolus and nucleoplasm. CDKN2AIPNL, and related CARF proteins, interact with key cell cycle regulators such as p53 and ARF, supporting cellular senescence, cell cycle arrest, and tumor suppression signaling pathways[2]. Its function in suppressing uncontrolled proliferation links it to cancer biology, though there is no evidence it is currently directly targeted by therapeutics or used as a biomarker[1][2][3][4].
- Other names
- CDKN2AIPNLCDKN2AIP N-terminal-like proteinCDKN2A-interacting protein N-terminal-like proteinC2AILMGC13017[1][3][4][8]
02
Biological functions
Cell cycle regulationSignal transductionRegulation of cell proliferationTumor suppression[1][2]
03
Disease associations
Cancer (implicated through cell cycle and tumor suppression pathways)[1][2]
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