CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)

CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) is the key enzyme responsible for catalyzing the formation of phosphatidylinositol from CDP-diacylglycerol and myo-inositol, representing the foundational step in the biosynthesis of all phosphoinositide species[1][2][3][4][5]. As an integral multi-pass membrane protein, primarily localized to the endoplasmic reticulum and Golgi apparatus, it is a member of the CDP-alcohol phosphatidyltransferase class-I family[4][5]. The product of its enzymatic action, phosphatidylinositol, serves as a precursor for numerous signaling molecules and lipid second messengers involved in signal transduction downstream of G protein-coupled receptors and tyrosine kinases, regulating essential cellular processes such as cell growth, calcium metabolism, and protein kinase C activity[2][5]. CDIPT function is essential for the formation of specialized endoplasmic reticulum domains, supports autophagosome biogenesis, and underpins healthy muscle structure and contraction[2][3][5]. Disruption of CDIPT impairs cellular membrane dynamics and muscle physiology, but there are currently no clinically approved drugs known to directly target this enzyme.

Other names

Phosphatidylinositol synthasePI synthasePISPIS1PtdIns synthase