CEA cell adhesion molecule 20 (CEACAM20)

CEA cell adhesion molecule 20 (CEACAM20) is a transmembrane glycoprotein member of the immunoglobulin superfamily, primarily expressed on the apical plasma membrane of intestinal epithelial cells[2][3][7]. CEACAM20 possesses four extracellular Ig-like domains and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic region[3]. Upon tyrosine phosphorylation, CEACAM20 binds to and activates spleen tyrosine kinase (SYK), leading to downstream activation of the NF-κB pathway and the subsequent production of pro-inflammatory cytokines such as CXCL8/IL-8 and IL-6[2][3][7]. It is a physiological substrate for the protein tyrosine phosphatase SAP-1, which regulates its phosphorylation status and hence the local immune response in the intestinal epithelium[3]. The detailed signaling roles and disease associations of CEACAM20 are still under investigation, but the CEACAM family as a whole is implicated in cancer biology, host-pathogen interaction, and immune modulation[1][5][6].

Other names

CEACAM20Cell adhesion molecule CEACAM20UNQ9366PRO34155GPAD9366CEA cell adhesion molecule 20Carcinoembryonic antigen-related cell adhesion molecule 20

Not targeted by specific drugs known to date; mechanisms described involve activation of SYK tyrosine kinase and downstream NF-κB signaling leading to inflammatory cytokine production[2][3][7]