CEBPA antisense RNA 1 (CEBPA-AS1)

CEBPA antisense RNA 1 (CEBPA-AS1, also known as CEBPA divergent transcript/ADINR) is a long noncoding RNA (lncRNA) transcribed in a head-to-head orientation relative to the CEBPA gene promoter. It functions as a positive regulator (enhancer RNA or elncRNA) for CEBPA transcription, acting in cis by maintaining active enhancer marks (notably, H3K27ac) and thereby increasing CEBPA expression. CEBPA-AS1 expression is tightly correlated with CEBPA mRNA in multiple cell types, and knockdown of CEBPA-AS1 reduces both CEBPA and its downstream targets such as albumin. As CEBPA is a master regulator of cell differentiation, metabolism, and cell cycle arrest, disruption of CEBPA-AS1 is implicated in various cancers and potentially metabolic diseases. While not a direct therapeutic target, CEBPA-AS1 is a key regulatory molecule at the CEBPA locus and a prospective biomarker for enhancer function and disease state.

Other names

CEBPA divergent transcriptCEBPA-DTADINRAdipogenic differentiation induced noncoding RNACEBPA antisense RNA 1 (head to head)CEBPA antisense RNA 1 (non-protein coding)

Antisense oligonucleotides (ASOs): Bind and promote degradation or block function of CEBPA-DT, reducing its enhancer activity and lowering CEBPA expression. Small activating RNAs (saRNAs): May function by altering associated lncRNA expression and positively regulate CEBPA transcription.