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Target intelligence / Profile preview
Carboxyl ester lipase (CEL)
- Target
- CEL
- Molecular classification
- Enzyme, Type-B carboxyl esterase/lipase
01
Overview
Carboxyl ester lipase (CEL), also known as bile salt-dependent lipase (BSDL) or bile salt-stimulated lipase (BSSL), is a glycoprotein enzyme primarily secreted by the pancreas and mammary gland. CEL plays a crucial role in lipid digestion and absorption, with broad substrate specificity for various lipid molecules including cholesteryl esters, triacylglycerols, phospholipids, and ceramides. Mutations in CEL are associated with Maturity-Onset Diabetes Of The Young type 8 (MODY8) and elevated serum levels are observed during acute pancreatitis.
- Other names
- BSDLBSSLBALCELLCEaseFAPFAPPLIPAMODY8Bile salt-dependent lipaseBile salt-stimulated lipaseCholesterol esterase
02
Mechanism of action
Hydrolyzes ester bonds in various lipid substrates, requiring bile salts for optimal activity
03
Biological functions
Lipid digestionLipid absorptionChylomicron assemblyCeramide hydrolysisHydrolyzes cholesteryl estersHydrolyzes triacylglycerolsHydrolyzes diacylglycerolsHydrolyzes monoacylglycerolsHydrolyzes phospholipidsHydrolyzes ceramidesHydrolyzes lipid-soluble vitamins
04
Disease associations
Maturity-Onset Diabetes Of The Young type 8 (MODY8)Acute pancreatitisAtherosclerosisChronic pancreatitisRheumatoid arthritisPsoriatic arthritis
05
Safety considerations
Potential cytotoxicity of certain CEL variantsLink to inflammatory disorders
06
Biomarkers
Serum CEL levels (elevated in acute pancreatitis)
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