Cell adhesion molecule 2 (CADM2)

Cell adhesion molecule 2 (CADM2) is a member of the immunoglobulin superfamily and the synaptic cell adhesion molecule (SynCAM) family, characterized by three extracellular Ig-like domains and a cytosolic protein 4.1 binding motif. CADM2 mediates cell–cell adhesion primarily in the brain, where it organizes synaptic connections, affects synaptic plasticity, and influences neuronal development, connectivity, and cognitive functions. It has emerged as a critical tumor suppressor, with loss or reduction of CADM2 expression observed in multiple cancer types and associated with increased cell proliferation, migration, invasion, and poor prognosis through effects on cell cycle progression and the epithelial–mesenchymal transition. Genetic variants in CADM2 are associated with a range of behavioral and metabolic traits, including impulsivity, body mass index, and risk-taking behaviors. CADM2 is highly enriched in the central nervous system, especially in the frontal cortex and striatum, but is also expressed in peripheral tissues. Although CADM2 is recognized as a potential therapeutic and diagnostic target, no direct pharmacological modulators are currently available.

Other names

IGSF4DNECL3SynCAM 2SynCAM2SynCAM-2IgSF4DNecl-3Immunoglobulin superfamily member 4DNectin-like protein 3synaptic cell adhesion molecule 2nectin-like 3