Cell binding domain of type I collagen

The cell binding domain of type I collagen is a specific peptide sequence within the larger type I collagen protein that mediates binding to cell-surface receptors, mainly integrins (e.g., α2β1) and fibronectin. These domains include motifs adjacent to the matrix metalloprotease-1 (MMP-1) cleavage site and other sites within the triple-helical region of collagen, often characterized by Gly-X-Y repeat motifs such as GFOGER or GLOGER. These regions facilitate cell adhesion, trigger intracellular signaling, and coordinate extracellular matrix remodeling essential for tissue homeostasis and development. The cell binding domain is instrumental in physiological processes like wound healing and pathological states, including cancer invasion and tissue fibrosis, but is not a discrete pharmacological target itself.

Other names

fibronectin-binding site of type I collagenintegrin-binding site of type I collagencollagen cell-binding motif

Not applicable as a standalone therapeutic target, but the mechanism for blockers is disruption of collagen–integrin or collagen–fibronectin interactions.