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Cell cycle G1 phase
- Molecular classification
- Other
01
Overview
The G1 phase, also known as Gap 1 or Growth 1 phase, is the first of four phases in the eukaryotic cell cycle. It occurs after mitosis and before DNA synthesis (S phase). During G1, the cell grows in size, synthesizes mRNA and proteins necessary for DNA replication, and accumulates organelles and energy reserves needed for subsequent cell division. The length and regulation of G1 are crucial for tissue homeostasis. Dysregulation at this stage can lead to uncontrolled proliferation—a hallmark of cancer. Environmental cues such as nutrient availability, temperature (~37°C optimal in humans), and space influence progression through G1.
- Other names
- G1 phaseGap 1Growth 1 phase
02
Biological functions
Cell cycleCell growthBiosynthesisPreparation for DNA replication
03
Disease associations
Cancer
04
Safety considerations
Dysregulation can lead to uncontrolled proliferation
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