Target intelligence / Profile preview

Cell Cycle Protein

Molecular classification: Protein, Enzyme, Kinase, Transcription factor, Regulator, Cyclin, Cyclin-dependent kinase (Cdk), Ubiquitin ligase complex

Overview

Cell cycle proteins are a class of molecules that regulate the progression and fidelity of the cell cycle, ensuring accurate DNA replication and division into daughter cells. Key examples are cyclins, cyclin-dependent kinases (Cdks), and ubiquitin ligase complexes. They regulate cell division by phosphorylating target substrates to trigger progression through the cell cycle phases and target proteins for degradation to ensure proper phase transitions. Dysregulation is implicated in cancer.

Mechanism of action

Inhibition of CDKs, targeting proteasome-mediated degradation pathways

Biological functions

Cell cycleDNA replicationChromosome segregationCell divisionRegulation of cell cycle phase transitionsPhosphorylationUbiquitinationProteolysis

Disease associations

CancerGenomic instabilityUncontrolled proliferation

Safety considerations

Potential for off-target effects due to the broad role of cell cycle proteinsDrug resistance

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