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Target intelligence / Profile preview
Cell cycle regulator cyclin D1 (Cyclin D1)
- Target
- Cyclin D1
- Molecular classification
- Cyclins
01
Overview
Cyclin D1 is a key cell cycle regulatory protein that controls the G1-S phase transition. It forms complexes with CDK4/CDK6, phosphorylating RB1 and promoting E2F-mediated transcription of genes required for DNA replication. Cyclin D1 expression is regulated by mitogenic signals and its degradation is essential for proper cell cycle control. Beyond its role with CDKs, Cyclin D1 has CDK-independent functions including modulation of transcription factor activity and regulation of cellular metabolism. Overexpression of cyclin D1 contributes significantly to tumorigenesis and is a potential biomarker in several cancers.
- Other names
- CCND1
02
Mechanism of action
CDK4/CDK6 inhibition
03
Biological functions
Cell cycleCell proliferationG1/S transitionTranscriptional regulationMetabolismCell migrationAngiogenesis
04
Disease associations
CancerBreast carcinomaMantle cell lymphoma
05
Safety considerations
Unchecked cell proliferationTumorigenesis
06
Biomarkers
Cyclin D1 overexpression (breast carcinoma)Cyclin D1 overexpression (mantle cell lymphoma)
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