Target intelligence / Profile preview

Cell death-inducing DFFA-like effector B

Molecular classification: Other

Overview

CIDEB is a member of the CIDE family of proteins, involved in lipid metabolism and apoptosis. It plays a critical role in lipid droplet fusion and regulation, and is essential for HCV entry into hepatocytes. Loss-of-function mutations are protective against liver disease and obesity.

Other names: CIDEBCell death inducing DFFA like effector b

Biological functions

Lipid droplet fusionRegulation of lipid droplet sizePositive regulation of apoptotic processesLipid metabolismVLDL biogenesis/secretion

Disease associations

Hepatitis C Virus InfectionMetabolic DisordersLiver disease

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