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Cell division control protein 42 homolog (Cdc42)
- Target
- Cdc42
- Molecular classification
- Small GTPase, Rho family GTPase
01
Overview
Cell division control protein 42 homolog (Cdc42) is a small GTPase of the Rho subfamily. It cycles between an active GTP-bound state and an inactive GDP-bound state, regulating multiple essential cellular processes including cell cycle progression, gene transcription, cytoskeletal dynamics, cell polarity, and neuronal development. Dysregulation or mutation can contribute to tumorigenesis as well as developmental disorders involving cytoskeletal abnormalities.
02
Mechanism of action
Inhibition of GTP binding or activation
03
Biological functions
Cell cycle progressionMitotic spindle orientationGene transcriptionCytoskeletal dynamicsActin polymerizationCell shape regulationCell motilityMicrotubule organizationEpithelial cell polarizationNeuronal developmentDendritic spine plasticityPodocyte functionT-cell homeostasis
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Dysregulation can contribute to tumorigenesisDevelopmental disorders involving cytoskeletal abnormalities
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