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Target intelligence / Profile preview
Cell Division Cycle 25 Homolog A (CDC25A)
- Target
- CDC25A
- Molecular classification
- Enzyme, Phosphatase, Dual-specificity phosphatase
01
Overview
Cell Division Cycle 25A (CDC25A) is a dual-specificity phosphatase essential for cell cycle regulation, specifically the G1 to S phase transition and mitosis. It activates cyclin-dependent kinases (CDKs) by removing inhibitory phosphate groups. CDC25A overexpression is linked to various cancers, correlating with high-grade tumors and poor prognosis. It acts as an oncogene by promoting uncontrolled cell cycle progression. Its activity is tightly regulated by checkpoint kinases like Chk1 and Chk2.
- Other names
- M-phase inducer phosphatase 1Dual specificity phosphatase Cdc25ACDC25 homolog A
02
Mechanism of action
Dephosphorylates and activates cyclin-dependent kinases (CDKs)
03
Biological functions
Cell cycleCell proliferationG1/S transitionMitosis regulationCDK activation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad CDK activationOveractivation can override normal checkpoint controlsInhibition can disrupt normal cell cycle progression
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