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Target intelligence / Profile preview
Cell Division Cycle 25 Homolog C
- Molecular classification
- Enzyme, Dual Specificity Phosphatase
01
Overview
Cell Division Cycle 25C (CDC25C) is a dual specificity phosphatase that plays a critical role in regulating the G2/M transition of the cell cycle. It activates cyclin B-bound CDK1 by dephosphorylation, triggering entry into mitosis. CDC25C is involved in DNA damage repair and its dysregulation is implicated in cancer development, making it a potential therapeutic target.
- Other names
- CDC25CM-phase inducer phosphatase 3Protein Phosphatase 1 Regulatory Subunit 60Dual Specificity Phosphatase CDC25CPPP1R60
02
Mechanism of action
Dephosphorylates cyclin B-bound CDK1, activating its kinase activity and triggering entry into mitosis
03
Biological functions
Cell cycleG2/M transitionDNA damage repairMitosis inductionDephosphorylation of cyclin B-bound CDK1
04
Disease associations
CancerTumorigenesisPlague
05
Safety considerations
Overexpression or dysregulation linked to uncontrolled proliferationPotential for promoting invasive growth, metastasis, drug resistance, and anti-apoptotic properties in tumor cells
06
Biomarkers
CDC25C expression level as a biomarker for malignancy
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