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Target intelligence / Profile preview
Cell Division Cycle 25A (CDC25A)
- Target
- CDC25A
- Molecular classification
- Enzyme, Dual specificity phosphatase
01
Overview
CDC25A is a dual specificity phosphatase that functions as a key mediator in the cell cycle, particularly in the G1/S transition phase. It acts by dephosphorylating and activating cyclin-dependent kinases (CDKs), such as CDK2 and CDK1, which are crucial for cell cycle progression. CDC25A is considered an oncogene due to its overexpression in various cancers, making it a target for anticancer therapies. It is also involved in DNA damage checkpoints, being degraded in response to DNA damage to halt cell cycle progression.
- Other names
- M-phase inducer phosphatase 1Dual Specificity Phosphatase Cdc25A
02
Mechanism of action
De-phosphorylation of CDKs (e.g., CDK2) to activate their kinase activity, leading to cell cycle progression
03
Biological functions
Signal transductionCell cycle progression (G1/S phase)Cell proliferation
04
Disease associations
Cancer, especially in tumors with overexpression
05
Safety considerations
Potential for enhanced cell proliferation leading to cancer progression
06
Interacting drugs
Anticancer drugs targeting cell cycle progression
07
Biomarkers
Overexpression levels in tumors
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