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Cell division cycle 25B (CDC25B)

Target: CDC25B
Molecular classification: Enzyme, Dual specificity phosphatase

Overview

Cell division cycle 25B (CDC25B) is a member of the CDC25 family of dual-specificity phosphatases. It plays a critical role in cell cycle regulation, particularly in controlling the transition from G2 phase to mitosis (M phase). CDC25B achieves this by activating cyclin-dependent kinase complexes, most notably CDK1/cyclin B, through dephosphorylation.

Other names: Dual Specificity Phosphatase Cdc25BM-Phase Inducer Phosphatase 2CDC25HU2

Mechanism of action

Dephosphorylation and activation of CDK1/cyclin B complex

Biological functions

Cell cycleRegulation of cell cycleMitosisDephosphorylation of CDKsMicrotubule nucleation and organization

Disease associations

CancerBreast CancerEsophageal Cancer

Safety considerations

Oncogenic potential

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