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Target intelligence / Profile preview
Cell division cycle 25B phosphatase (CDC25B)
- Target
- CDC25B
- Molecular classification
- Enzyme, Phosphatase, Dual-specificity phosphatase
01
Overview
Cell division cycle 25B phosphatase (CDC25B) is a dual-specificity phosphatase that plays a critical role in cell cycle regulation, particularly in controlling the transition from G2 phase to mitosis (M phase). It activates cyclin-dependent kinase 1 (CDK1, also known as CDC2) by dephosphorylating inhibitory sites, which is essential for mitotic entry. CDC25B exhibits oncogenic properties, and is a considered a potential therapeutic target in cancer treatment strategies aiming to disrupt aberrant cell division.
- Other names
- M-phase inducer phosphatase 2
02
Mechanism of action
Inhibition of CDC25B phosphatase activity, leading to cell cycle arrest.
03
Biological functions
Cell cycleCell proliferationRegulation of CDK1/CDC2 activityG2/M transitionRecovery from DNA damage-induced G2-M checkpoint arrestAbscission
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the presence of other CDC25 family members.Disruption of normal cell cycle progression in non-cancerous cells.The precise role in cancer development remains under investigation.
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