Target intelligence / Profile preview

Cell division cycle 37 (CDC37)

Target: CDC37
Molecular classification: Molecular chaperone, Co-chaperone

Overview

The CDC37 protein is a molecular co-chaperone that works with heat shock protein 90 (Hsp90) to stabilize and activate various protein kinases crucial for signal transduction and the cell cycle. It plays a significant role in directing Hsp90 to its target kinases, influencing cell proliferation and survival. Its dysfunction can affect cell cycle progression and is implicated in cancer and other diseases.

Other names: Cdc37Cell division cycle control protein 37

Mechanism of action

Indirectly involved in mechanisms targeting Hsp90, such as disrupting protein kinase stability.

Biological functions

Signal transductionCell cycle regulationProtein kinase stabilization

Disease associations

Cancer: CDC37's role in stabilizing various kinases implicated in cancer progression.Cardiovascular disease: Interaction with eNOS suggests potential implications in cardiovascular health.

Safety considerations

Its role in cell cycle regulation and stabilization of kinases means perturbing its function could have broad cellular effects, potentially impacting cell viability and proliferation.

Interacting drugs

geldanamycin

1 more in the full profile.

Biomarkers

Not specifically identified as a biomarker itself, but its association with various kinases and cellular processes makes it relevant in contexts where these kinases are biomarkers.

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