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Target intelligence / Profile preview
Cell division cycle 7-related protein kinase (CDC7)
- Target
- CDC7
- Molecular classification
- Serine/threonine-specific protein kinase, Enzyme
01
Overview
Cell division cycle 7-related protein kinase (CDC7) is a serine/threonine protein kinase essential for the initiation of DNA replication during the cell cycle. It phosphorylates components of the minichromosome maintenance (MCM) complex, allowing DNA replication to begin. CDC7's overexpression is linked to tumorigenesis, making it a therapeutic target in oncology. Inhibiting CDC7 impairs cancer cells' ability to respond to replication stress, leading to DNA damage and apoptosis. Several inhibitors, such as SGR-2921, are under clinical investigation. CDC7 expression peaks functionally during S phase and is regulated post-transcriptionally by microRNAs. The CDC7 gene is highly conserved across eukaryotes.
- Other names
- CDC7L1
02
Mechanism of action
Selective inhibition of CDC7 kinase activity
03
Biological functions
Cell cycleDNA replication initiationSmooth muscle cell differentiationRegulation of TGF-beta signaling
04
Disease associations
CancerNeoplastic transformationTumorigenesis
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesChallenges in achieving selective inhibition in vivoPossible disruption of normal cell cycle processes
06
Interacting drugs
SGR-2921
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