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Target intelligence / Profile preview
Cell Division Cycle Associated 1
- Molecular classification
- Cell Division Cycle Associated (CDCA) protein, Kinetochore protein, Oncoantigen
01
Overview
Cell Division Cycle Associated 1 (CDCA1), also known as NUF2 or NUF1, is a core component of the NDC80 kinetochore complex and is essential for stable attachment of spindle microtubules to kinetochores during mitotic prophase. CDCA1 plays a crucial role in accurate chromosome segregation during cell division, and its dysregulation is linked to various cancers, making it a potential therapeutic target and biomarker.
- Other names
- NUF2NUF1
02
Mechanism of action
CDCA1 downregulation induces apoptosis via mitochondrial-dependent and caspase-dependent pathways.
03
Biological functions
Kinetochore-microtubule attachmentChromosome segregation during mitosisRegulation of cell cycleApoptosis
04
Disease associations
Cancer
05
Safety considerations
Dysregulation of CDCA1 can lead to aberrant cell division and tumorigenesis.
06
Biomarkers
CDCA1 overexpression as a diagnostic/prognostic biomarker for cancer
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