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Target intelligence / Profile preview
Cell Division Cycle Associated 1 Protein (CDCA1)
- Target
- CDCA1
- Molecular classification
- Protein, Kinetochore Component
01
Overview
Cell division cycle associated 1 protein (CDCA1), also known as NUF2, is a key component of the NDC80 kinetochore complex. This protein plays an essential role in chromosome segregation during mitosis by stabilizing microtubule attachment at kinetochores. CDCA1 is overexpressed in various cancers, making it a potential prognostic marker and therapeutic target. Its restricted normal tissue distribution but high tumor specificity makes it a promising candidate for targeted anti-cancer therapies.
- Other names
- NUF2CT106NUF2R
02
Mechanism of action
RNA interference targeting CDCA1, peptide vaccines, molecular-targeted therapies
03
Biological functions
Kinetochore-microtubule attachmentChromosome segregationSpindle checkpoint controlCell cycle
04
Disease associations
CancerMelanomaColorectal CancerOral Cavity Carcinoma
05
Safety considerations
Potential off-target effects of therapiesDisruption of normal cell division in healthy tissues (if not targeted effectively)
06
Biomarkers
CDCA1 expression levels in tumorsHigh CDCA1 expression as a prognostic marker
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